Nighttime Eye Ointments for Overnight Relief

All Artificial Tears

Preservative-Free (PF)

Gels & Ointments

Single-Dose Containers
Filter Right
4 products
Best sellingAlphabetically, A-ZAlphabetically, Z-APrice, low to highPrice, high to lowDate, old to newDate, new to old
Filter Right
4 products
Best sellingAlphabetically, A-ZAlphabetically, Z-APrice, low to highPrice, high to lowDate, old to newDate, new to old

Filter

Out of stock
Price
Down
$
$
Brand
Down
Sort by
Down

Nighttime Eye Protection & Ointments – Dry Eye Relief While You Sleep

Wake up with more comfortable, hydrated eyes. Our Nighttime Protection & Ointments collection is specifically designed to treat dry eye symptoms that worsen overnight due to tear evaporation, incomplete eyelid closure (lagophthalmos), or CPAP-related air leaks.

Many people with dry eye disease experience worsening symptoms in the morning due to the absence of blinking and reduced tear production during sleep. That’s where overnight eye protection becomes essential.

Who Should Use Nighttime Eye Protection?

  • People with chronic dry eye or nocturnal lagophthalmos

  • Patients recovering from corneal surgery

  • Individuals with recurrent corneal erosions

  • CPAP users experiencing dry eyes from air leaks

  • Anyone needing long-lasting nighttime relief

These solutions are ophthalmologist-recommended for patients seeking overnight protection and symptom relief. Pair your daytime routine with nighttime ointments and masks for 24-hour dry eye care.

OPTASE® HYLO Night™ Eye Ointment Optase -
Only 6 left!
Left Right Quick buy
Optase
OPTASE® HYLO Night™ Eye Ointment
$16.95
Write a review
SYSTANE® NIGHTTIME Eye Ointment Alcon -
Only 3 left!
Quick buy
Alcon
Systane® Nighttime Eye Ointment
$13.99
Write a review
Save $2.00
Left Right Quick buy
Refresh
REFRESH® RELIEVA™ PF Multidose
$16.95 $18.95 Sold Out
Write a review
Save $2.00
Left Right Quick buy
Refresh
REFRESH P.M.® Preservative-Free lubricating eye ointment
$12.95 $14.95 Sold Out
Write a review

Nighttime Eye Ointments for Overnight Relief FAQ

Why do my eyes feel worse in the morning?

Dry eye symptoms often worsen overnight due to reduced tear production, incomplete eyelid closure, or environmental factors like fans and CPAP air leaks.

What’s the difference between ointments and drops?

Ointments are thicker than drops and provide longer-lasting moisture. They can blur vision temporarily, so they’re best used before bedtime.

Can I use a mask and ointment together?

Yes, many users apply a lubricating ointment and wear a moisture-sealing mask over it to maximize hydration and healing while they sleep.