Comparing supplements by bottle size or “1,000 mg fish oil” can be misleading. The meaningful figures are the full daily EPA and DHA amounts, oil form, added nutrients and labelled serving.

The table below uses current EyeDropShop.com product information. Formulas can change, so confirm the Supplement Facts panel before purchasing.

Why PRN De3 earns the “top dry-eye omega” position

PRN De3 is not the winner of every category. It is the strongest all-around omega-3 in this group when the decision is based on combined EPA+DHA dose, rTG form, a deliberately high EPA percentage, vitamin D3 and direct formula-specific dry-eye studies.

Its 1,680 mg EPA and combined 2,240 mg EPA+DHA are the highest in this comparison. Those amounts match the core formula used in published randomized dry-eye trials. That is a substantive difference, not simply brand prestige. For the nuance behind those trials, read our balanced PRN De3 evidence review.

PRN De3 vs HydroEye

HydroEye is not trying to maximize marine EPA and DHA. Its daily serving provides 100 mg EPA and 70 mg DHA alongside 1,570 mg black currant seed oil, a source of GLA, plus nutrient cofactors. Four capsules are taken daily.

PRN is the clearer fit when the priority is a concentrated, high-EPA rTG fish-oil formula. HydroEye is the more distinct choice when someone specifically wants a GLA-centered formula with a broader ingredient matrix.

PRN De3 vs EyePromise EZ Tears

EZ Tears provides 590 mg EPA and 440 mg DHA in triglyceride form in two softgels. It also includes vitamins A, D3 and E, evening primrose oil, turmeric, green tea and mixed tocopherols/tocotrienols.

PRN delivers more than twice the combined EPA+DHA and uses a 3:1 EPA:DHA profile. EZ Tears offers fewer capsules and a broader multi-nutrient approach. More ingredients do not automatically mean a better result; they mean a different formulation strategy.

PRN De3 vs OcuSci Ultra Dry Eye TG

OcuSci supplies 974 mg EPA and 487 mg DHA in triglyceride form, plus omega-7, lutein, zeaxanthin, vitamin D3 and vitamin B12. The daily serving is five smaller softgels.

PRN provides 779 mg more combined EPA+DHA with fewer capsules and has the more EPA-forward ratio. OcuSci may appeal to shoppers who want omega-3 packaged with macular-support nutrients and omega-7.

PRN De3 vs PRN Omega-V

Omega-V uses algae rather than fish and provides 330 mg EPA plus 670 mg DHA per teaspoon. It is vegan, non-GMO and DHA-dominant—the reverse of PRN De3's EPA-forward profile.

For a fish-free liquid, Omega-V is the obvious comparison. For the higher combined dose and the formula used in PRN-related dry-eye studies, De3 remains the closer match.

What about generic fish oil?

A generic can be high quality, but compare active ingredients. A label that says “1,000 mg fish oil” may provide far less EPA and DHA. Matching PRN's 2,240 mg could require many capsules. Also check whether the oil is triglyceride, rTG or ethyl ester and whether independent purity data are available.

Price per bottle is therefore less informative than price per 1,000 mg EPA+DHA at the intended daily serving. Even then, a lower-cost option should be compared on form, tolerability and quality—not just milligrams.

Which product fits which priority?

• Highest combined EPA+DHA and high-EPA rTG formula: PRN De3.
• GLA-centered formula: HydroEye.
• Two-softgel, broad nutrient blend: EyePromise EZ Tears.
• Omega-3 plus omega-7 and macular nutrients: OcuSci Ultra Dry Eye TG.
• Vegan, non-fish liquid EPA/DHA: PRN Omega-V.

Frequently asked questions

Is PRN De3 worth the premium?

It offers the highest EPA+DHA dose in this comparison, rTG form, vitamin D3 and formula-specific dry-eye studies. Whether those differences justify the price depends on response, budget and professional advice.

Which has the fewest capsules?

EZ Tears uses two softgels daily; PRN De3 uses three; HydroEye uses four; OcuSci uses five. Omega-V is a once-daily liquid teaspoon rather than a capsule.

Can I combine two products?

Do not stack them without reviewing total EPA, DHA, vitamin D, vitamin A and bleeding risk with a pharmacist or physician.

Sources

• PRN De3
• HydroEye
• EyePromise EZ Tears
• OcuSci Ultra Dry Eye TG
• PRN Omega-V
• Epitropoulos et al., 2016

Product details may change. Check the current U.S. label and consult a healthcare professional. Dietary supplement statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure or prevent disease.